ANTI-MALARIAL DRUG IN HUMAN CLINICAL TRIAL STAGE
Ranbaxy Laboratories Limited (Ranbaxy) and Medicines for Malaria Venture (MMV) have taken a potential breakthrough anti malarial drug into human clinical trial stage. Ranbaxy, MMV's pharmaceutical partner for the development of this drug, has obtained authorisation from Medicines and Healthcare Products Regulatory Agency (MHPRA) to conduct clinical trials in the United Kingdom (UK).
This is the first regulatory step in new drug development after safety and drug activity is established in the pre-clinical phase.
The drug code named OZ277/RBx11160, is currently being evaluated in a Phase I study for its safety, tolerability and pharmacokinetics (PK)in humans in the UK . A synthetic peroxide, the drug is believed to have similar mode of action as the most effective anti malarial drug currently available Artemisinin,a herbal remedy based on he Artemisia annua plant.
However, because of the costly and lengthy extraction process from the plant, Artemisinins are at least ten times more expensive than the cheap standard anti malarials.
Although Artemisinin based combination therapies (ACTs) are currently the best cure for drug resistant malaria, access to ACTs, in disease endemic countries has been limited due to their cost. An effective synthetic drug would be superior to the current ACTs as it will not be dependent on the artemisia plant and will likely be much cheaper to manufacture.
POWER FROM VEGETABLE WASTE
This article deals with the production process of electricity from biodegradable solid vegetable waste by means of biomethanation technique.
Power units with vegetable waste as fuel are being successfully operated in several developed countries.
A biomethanation plant is under installation in Koyambedu near Chennai , India to produce 15 MW power with vegetable wastes as raw material.
MORINGA-EXCITING PROSPECTS
Moringa is a tough tree that survives in poor soils and uses its deep tap root to survive long periods of drought. It is easy to propagate from seeds and cuttings. It grows rapidly to six meters in height and can flower and fruit in one year.
In recent times, considerable efforts have been launched in Africa to promote the cultivation of Moringa and develop its application. India appears to be lagging behind the international efforts in this regard.
The successful development of value addition to Moringa would enable expansion of the area of Moringa cultivation significantly in India , which would provide considerable boost to agricultural sector., particularly in today's water scarce conditions in several parts of the country, since Moringa can withstand drought conditions.
STROBILURIN -EMERGING FUNGICIDE
One of the more exciting advances in disease control in agriculture during the last decade has been the discovery, development and marketing of strobilurin fungicides.
Chemically, the strobilurins are a unique class of fungicidal compounds derived from or related to oudemansin or strobilurin A, These compounds inhibit other fungi that could compete for nutrients in the rotting plant material.
The original compound Strobilurin A. was isolated from a fungus called Strobiluris tenacellus, which was found on decaying wood in a European forest .
There are three active ingredients in the Strobilurin fungicide type - kresoxim-methyl and, more recently, azoxystrobin and trifloxystrobin.
Several companies have developed synthetic strobilurin products.
More details are provided in the article.
NEOPENTYL GLYCOL – PRODUCT PROFILE
In this article, following aspects are discussed:
Description
Specifications
Application sector
Packaging
Storage
Global Players
Price
Global demand trends
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